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Early life antibiotics impact long-term metabolic health and blood transcriptome in the pig

 © Ben Willing
Mis à jour le 27/06/2016
Publié le 20/06/2016
Mots-clés : CONFÉRENCES
 © Ben Willing
© Ben Willing

Ben Willing

Assistant Professor, Canada Research Chair in Microbiology of Nutrigenomics
Department of Agricultural, Food and Nutritional Science
University of Alberta, Canada

 

Vendredi 24 juin 2016 à 11h00
 Centre de Jouy-en-Josas
Amphithéâtre, bâtiment 442

Résumé

Epidemiological evidence suggests that antibiotic exposures in early life results in reduced long-term health outcomes and several experimental studies have now shown that the relationship is causal. My team is particularly interested in the effects of early life antibiotic exposure on the development of metabolic disease and Salmonella resistance. We study host-microbial interactions in the pig with interest in increasing disease resistance and reducing the need for antibiotics, as well as using the piglet as a biomedical model for infant development. We have generated compelling data that early life antibiotic exposure impacts the long-term blood transcriptome, with predicted relevance to Salmonella resistance. Furthermore, we have shown that early life antibiotic exposure impacts islet development in the pancreas, with consequences on the ability to handle a glucose challenge later in life.

Invité par Claire Rogel-Gaillard, UMR1313 Génétique Animale et Biologie Intégrative