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Developmental toxicity of nanomaterials – evidence from mouse studies

Updated on 09/04/2018
Published on 08/27/2018
Keywords: CONFÉRENCES

Wednesday September 12, 15h00

INRA IdF Jouy-en-Josas

Room 271, building 231

Abstract

Several recent studies in rodents have confirmed the existence of an association between the exposition to particles during pregnancy and the induction of many physiological changes in progeny. As a consequence, studies using airways for exposition indicate mainly functionnal changes in progeny, in for example, the central nervous system, the male reproductive system and the cardiovascular system.

Several plausible toxicologial mechanisms have been described. We have already found that the inhalation by the mother of particles modifies the expression of genes in the liver of her progeny; it may induce mutations, modify male reproductive parameters and affect the central nervous system as it is developed. Even though the data that currently exist are sufficient to formulate hypotheses, the huge variation in study design and the paticles tested hinder generalization and risk assessment. It is therefore necessary to repeat studies to confirm previous results. I will give an overview of the different studies that we have conducted to focus on the reproducibility of the results from one study to another.

  • Invited by Anne Couturier-Tarrade, UMR 1198 Biologie du Développement et Reproduction